Flow Chemistry Europe 2020 Agenda

Conference Registration, Coffee and Danish Breakfast

Welcome Address: Ferenc Darvas, Chairman, Flow Chemistry Society

Session Chair: Victor Sans Sangorrin, Group Leader, University Jaume I

Timothy Noël, Associate Professor, Eindhoven University of Technology
Flash Chemistry – The Flow Work of Prof. Jun-ichi Yoshida
In this presentation, we will give a selection of Prof. Jun-ichi Yoshida’s most memorable flow chemistry work.

Session: Industry 4.0 (Includes Machine Learning, Automation, Multistep Reaction Integration)

Richard Bourne, Associate Professor, University of Leeds
Digital Manufacturing of Pharmaceuticals
This talk will focus on the use of digitisation to enable more rapid automation of flow chemistry processes. This talk will cover the combination of inline analysis, machine learning algorithms and pharmaceutical process control to provide autonomous platforms for fast, robust development of manufacturing challenges.

Kerry Gilmore, Group Leader, Max Planck Potsdam
21st Century Synthesis
A platform for automated synthesis of small organic molecules based on a radial assembly of flow modules offers numerous advantages to traditional approaches and complements the needs of machine learning.

Networking with Exhibitors and Coffee

Session: Alternative Activiation Modes (IncludesPhotochemistry, Electrochemistry and Nanochemistry)

Thomas Wirth, Professor, Cardiff University
Synthesis of Natural Products using Flow Chemistry
We report on the flow synthesis of various natural products by developing methods for key transformations such as singlet oxygen generation an electrochemical aryl couplings.

Duncan Browne, Associate Professor, UCL
Continuous Flow as an Opportunity for Collaborative Science
Over the recent years our research team has participated in a number of collaborative projects, both internationally and across scientific disciplines with the common theme of using continuous flow to add value to these projects – this talk will give an account of how flow chemistry has supported these investigations.

Lee Edwards, Senior Investigator, GSK
Development of a Commercial Photoreactor System for HTS, Batch and Flow Scale Up Designed for Process Chemists
Having identified inconsistencies when repeating literature examples of photochemical transformations and difficulties recreating experimental setups, we designed a versatile modular photoreactor for high throughput screening, preparative scale batch reactions and continuous processing, all with a single light source. 

David Cantillo, Associate Professor, University of Graz
Electroorganic Synthesis Enabled by Microreactors
Continuous flow electrochemical cells are fundamental for the scale up of electroorganic synthesis. In some cases they can also succeed in transformations difficult to perform in batch on lab scale. Selected examples from our group will be presented.

Networking with Exhibitors and Lunch


“Magritek will be presenting a live instrument and offer insights on how the capabilities of benchtop NMR spectroscopy can help with applications in your lab. Please register here for the workshop.”

Session Chair: Gianvito Vile, Group Leader and PI, Politecnico di Milano and Fondazione Bracco

Victor Sans Sangorrin, Group Leader, University Jaume I
Integrating Enabling Technologies with Additive Manufacturing
In this talk the last results in the development of advanced micro and millifluidic chemical reactors will be presented. Additive manufacturing enables the development of innovative reactor architectures, allowing to easily integrate multiple enabling technologies in single and integrated devices.
Session: Biocatalytic or Biobased Flow Chemistry (Includes Enzymes, Biobased Molecular Conversion)

Francesco Mutti, Associate Professor, University of Amsterdam
Continuous Flow Biocatalysis for the Synthesis of Chiral Amines
Enzyme immobilization is gaining importance for continuous flow biocatalysis using isolated enzymes. This lecture will focus on the kinetic resolution of racemic amines and asymmetric amination of prochiral ketones using immobilized ω-transaminases in continuous flow systems and in different reaction media.

Jean-Christophe Monbaliu, Associate Professor, University of Liege
Continuous Flow Upgrading of Biobased Platforms
This lecture illustrates our latest efforts for the design of scalable strategies for the upgrading of biobased platform molecules toward high value-added compounds.

Networking with Exhibitors and Coffee

Oliver Kappe, Professor, University of Graz
Maximizing the Benefits of Flow: It’s all About Mixing…
In this presentation examples of flow chemistry will be highlighted that involve microreaction technology to intensify mass transfer. Exquisite mixing using microstructured devices allows chemistry to be performed that cannot be performed in batch mode.

Company Presentations

Poster Party with Beer, Wine and Pizza

Close of Day 1

Conference Registration, Coffee and Danish Breakfast

Session Chair: Francesca Paradisi, Professor, University of Bern
Session: Solids Handling in Flow

Bart Rimez, Senior Researcher, VU Brussels
Dimension-driven Capillary Reactor Design for Continuous Crystallization Operations
The creation and design of capillary crystallization reactors are discussed and how the separation between nucleation and growth of crystals can be achieved to overcome clogging issues.

Simon Kuhn, Associate Professor, KU Leven
Controlled Particle Formation in Microreactors
Different microfluidic reactor designs and operational strategies are presented to enable continuous manufacturing in the presence of solid particles, ranging from the crystallization of organic molecules to inorganic precipitates.

Alastair Florence, Professor, University of Strathclyde
Progress and Challenges for Continuous Manufacturing and Crystallisation Research
The talk aims to provide an overview of developments in continuous manufacturing research, highlighting recent progress across the development of predictive design tools and modular, integrated continuous drug substance and drug product processing activities.

Norbert Kockmann, Professor, Technical University Dortmund
Continuous Crystallization and Solids Handling in Flow
Strategies for continuous and robust processing will be discussed in this presentation.

Networking with Exhibitors and Coffee

Session: 3D-printing of Microreactors

Heidi Gruber-Wolfler, Associate Professor, TU Graz
3D Printing as a Powerful Tool to Produce Micro/Millifluidic Devices for Reactions and Analysis in Continuous Flow
Within this talk our approaches to design customized 3D printed micro/millifluidic devices will be presented. The applications of the components include chemical synthesis, particle detection as well as reaction calorimetry in continuous flow.

Filipe Viela, Assistant Professor, Heriot Watt University
Photocatalytic Reactionware in Flow: A New Paradigm for Photochemistry
This talk will describe the development and implementation of metal-free, 3D printed reactionware that can harvest light and mediate chemical reactions in continuous flow processes.

Francesca Paradisi, Professor, University of Bern
Progress in Flow Biocatalysts: Multi-enzyme Cascades and Implementation
Multi-step syntheses which are enzyme mediated, resemble closely (artificial) metabolic pathways which can be assembled in continuous. Here we present how we use flow technology to enable enzymatic cascades for the synthesis of target products. Scale-up of the selected processes will also be showcased.

Networking with Exhibitors and Lunch

Round Table Discussion: Standardization of the Flow Chemistry Field
Objective: Highlight and discuss the long-time unsolved problem of standardization of the field
Panelists: Professor Steven Ley, Cambridge University; Professor Timothy Noël, Eindhoven University of Technology; Dr Ferenc Darvas, Flow Chemistry Society; Dr Gellért Sipos, ThalesNano

Session Chair: Duncan Browne, Associate Professor, UCL
Session: Industrial Flow Chemistry

Mike DiMaso, Merck
The Development of a Green and Sustainable Manufacturing Process for Gefapixant
This talk will explore the synthetic challenges encountered in the development of the commercial route for Gefapixant (MK-7264) and demonstrate how the use of flow chemistry allowed for significant improvements to the key step of the synthesis.

Comfort Break

Michael Gottfried, Head of Reaction & Reactor Engineering, Bayer
Flow Chemistry – Industrial Aspects of a Promising Process Concept
The presentation will address strategic drivers for the pharmaceutical industry to engage in flow chemistry and later in continuous processing. Further more lessons learnt from current case studies in different scales will be summarized.

Gianvito Vile, Group Leader and PI, Politecnico di Milano and Fondazione Bracco
Expanding the Chemical Space with Flow Chemistry, Microreactor Engineering, and Process Intensification
Flow chemistry, microreactor engineering, and process intensification are revolutionizing the pharmaceutical industry and benefits of these technologies are seen throughout all areas of the pharmaceutical pipeline, from library synthesis in discovery to multistep reactions in chemical development. In this talk, I will discuss recent examples of novel, selective, and sustainable flow methodologies for the synthesis of scaffolds, building blocks, and final APIs.

Maarten Honing, Professor, University of Maastricht

Integration of Advanced APPI-Ion Mobility Technologies and Multiple “Physical Parameter” Microsensors with (Micro)fluidic Chemical Reactors
In this presentation the application of APPI-IMS-M/MS strategies and the combination with physical parametsr detection for a variety of chemical conversion systems with be discussed. The results will be placed within the context of process Analytical Technologies in flow-chemistry.

Closing Remarks: Ferenc Darvas, Chairman, Flow Chemistry Society

Close of Conference